Sent to Mexico to buy a bull, a Wyoming cowhand (Doug McClure) teams up with three Texas Rangers to solve a robbery/murder.

Bronson and Marvin star as murderous half-brothers who are running from the law as well as each other. A climatic confrontation proves to each of them just how mean the other can be. "The Meanest Men in the West" is actually an amalgam of two episodes of the hit 1960's TV series, "The Virginian." In one installment, a wealthy man's daughter is kidnapped by a nasty gunslinger. But the crime is only just a means for the ruffian to draw the tough title character into a blood- thirsty revenge scheme. In the second, a drifter burglarizes the Shiloh ranch. Then an unhinged girl relies on the man to aid in her flight from home.

A young girl comes to an embittered town and confronts its attitude with her determination to see the best in life.

When the local sheriff is killed after a bank robbery, ex-lawman Ben Cutler collars the apparent killer, Eddie Campbell. Because of his background as a local youth who spent time living with the Cutlers, Eddie gets the benefit of the doubt from Ben's daughter and his wife-to-be. Ben is firm in his belief that Eddie is guilty, and as the matter is debated in a divisive court battle, it will soon become clear whether he's right.

An ex-lawman is hired to transport gold from a mining community through dangerous territory. But what he doesn't realize is that his partner and old friend is plotting to double-cross him.

At the end of the Civil War, a Confederate team is ordered to rob a Union payroll train but the war ends leaving these men with their Union loot, until the Feds come looking for it.