The series is about a girl named Momo who attends high school at the city of Sorasaki. However, she is secretly a member of Tsukikage, an intelligence agency that protects people. As a new member of the agency, she works alongside her colleagues including her senior Yuki and friends. Together, they work to establish peace in the city.

"A girl in a lower grade just made me cry!" One day, Senpai visits the library after school and becomes the target of a super sadistic junior! The name of the girl who teases, torments, and tantalizes Senpai is "Nagatoro!" She's annoying yet adorable. It's painful, but you still want to be by her side. This is a story about an extremely sadistic and temperamental girl and you'll feel something awaken inside of you.

Yayoi Sakamoto, a diehard fan of comedians and comedy acts, enrolls in the private Kazuki High School in Nanba (Osaka's entertainment district famous as the starting point for many comedians). She reunites with Yomogi Takahashi, a childhood friend who once formed the comedy duo "Konamonzu" with her when they were little. Before long, they find themselves putting together a routine at a park like they did before, in order to enter a local shopping area's contest. At that moment, a mysterious girl calls out to them.