A group of mysterious white-haired children has been spotted at different times and places in Europe for over 500 years. Always with the looks of 11 years old, they behave way more mature than they should be, never grow, and seem to have supernatural power. What they have kept being after is a girl, and all the connection they have is a picture with a crescent moon. Now, in the year of 2012, an athletic boy named Tohma is about to be involved in this centuries-long mystery.

In the midst of societal conflict in the futuristic city of Metropolis, Kenichi and his uncle Shunsaku Ban set out to uncover the mystery behind the first human-like robot, Tima.

The future’s looking bleak. It’s a good thing there’s a new sheriff in town. Her name is Jo and she’s an enigma even to herself. Alongside her partners Sei, Amy, and Meg, Jo fights for the citizens who can’t defend themselves. Confronting corruption and twisted science, these gals are on fire—and they’re the best chance the wounded city’s got.