Count Dracula returns to the world of humans accompanied by Frankenstein's Monster, the Wolfman, the Mummy, and the Gillman. The uglies are in search of a powerful amulet that will grant them the ability to rule the world. A group of horror-loving heroes are the only ones daring to stand in their way.

In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.

The mega corporation Omni Consumer Products is still bent on creating their pet project, Delta City, to replace the rotting city of Detroit. Unfortunately, the inhabitants of the area have no intention of abandoning their homes simply for desires of the company. To this end, OCP have decided to force them to leave by employing a ruthless mercenary army to attack and harass them. An underground resistance begins and in this fight, RoboCop must decide where his loyalties lie.