Count Dracula returns to the world of humans accompanied by Frankenstein's Monster, the Wolfman, the Mummy, and the Gillman. The uglies are in search of a powerful amulet that will grant them the ability to rule the world. A group of horror-loving heroes are the only ones daring to stand in their way.

In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.