This musical is based on four short stories by Damon Runyon. In one tale, gambler Feet Samuels sells his body to science just as he realizes that Hortense loves him and that he would rather live than die. In another story, Harriet's parrot is killed, and she has problems dealing with her loss. Then, there is a gambler, "Regret", who has bloodhounds on his trail when he becomes a murder suspect. Finally, "The Brain" is bleeding profusely, and his friends search for a way to save his life through a blood transfusion.

A Texan with a secret past searches Europe with his son after the KGB kidnaps his wife.

When one of his patients is found murdered, psychiatrist Dr. Sam Rice is visited by the investigating officer but refuses to give up any information. He's then visited by the patient's mistress, Brooke Reynolds, whom he quickly falls for despite her being a likely murder suspect. As the police pressure on him intensifies, Rice decides to attempt solving the case on his own and soon discovers that someone is trying to kill him as well.

A young widow still grieving over the death of her husband finds herself being comforted by a local housepainter.