Billie Holiday spent much of her career being adored by fans. In the 1940s, the government targeted Holiday in a growing effort to racialize the war on drugs, ultimately aiming to stop her from singing her controversial ballad, "Strange Fruit."

Mikey and Rose are professional assassins. They are also lovers, and once upon a time Rose also knew Mikey's father. During an elaborate hit job for a malicious gangster, Rose fails to kill the main target, the gangster's pregnant girlfriend. Instead, she delivers her baby and convinces Mikey to help her protect them both. As Rose weakens from cancer, Mikey becomes breadwinner for this unusual family. But tranquility will not last.

Cecil Gaines was a sharecropper's son who grew up in the 1920s as a domestic servant for the white family who casually destroyed his. Eventually striking out on his own, Cecil becomes a hotel valet of such efficiency and discreteness in the 1950s that he becomes a butler in the White House itself. There, Cecil would serve numerous US Presidents over the decades as a passive witness of history with the American Civil Rights Movement gaining momentum even as his family has troubles of its own. As his wife, Gloria, struggles with alcoholism and his defiant eldest son, Louis, strives for a just world, Cecil must decide whether he should take action in his own way.

Ebony Jackson, a struggling single mother fighting her personal demons, moves her family into a new home for a fresh start. But when strange occurrences inside the home raise the suspicions of Child Protective Services and threaten to tear the family apart, Ebony soon finds herself locked in a battle for her life and the souls of her children.

A reporter returns to his Florida hometown to investigate a case involving a death row inmate.