Clayton Pierce is an agent working under deep cover. Although he is a top agent, he is questioning his loyalty after twenty years of service. His devotion has already cost him his wife, family and personal life. During a de-briefing from his last assignment, he is unknowingly administered the drug Oblivion, which destroys brain cells causing permanent memory loss. Within a few days of injection, the drug's effects become irreversible. Clayton will not only lose his memory, he will lose his identity as well. He realizes he can no longer rely on anyone at the agency to help him, not even his boss, Agent LaNova. With nowhere left to go, he appeals to his ex-wife, Kate, for help. Clayton and Kate must locate the antidote before it's too late.

Swarthy Paul Yeager arrives in New Orleans, and promptly gets a job bartending at La Cage du Verre, a show bar where his former girlfriend Jacqueline is a dancer and the moll of its sadistic owner, Marko. He and Jacqueline smuggle diamonds and drugs, with the local police detective in on the take. Even though Paul is ex-CIA, he's not undercover, he just wants to win Jacqueline back. His CIA pals from black ops are on hand hoping to arrest Marko's boss. Detective Montrachet finds out Paul's past and sets up a double cross. Her aims are less clear: to get back with Paul, to stay with Marko, or to run her own scam and scamper away?