The murder of the ex-wife of Doctor Sam Charney (Rutger Hauer) leads Detective Della Wilder (Pam Grier) to uncover a series of women's murders somehow linked to a big pharmaceutical company.

A man with an unknown disease travels to an island with his girlfriend where his relatives once lived, hoping to find a cure to his illness. Although his relatives were all thought to be dead, he finds them living underground.

Harry Palmer heads a private investigation business based in Moscow. His associates are Nikolai "Nick" Petrov, ex-CIA agent Craig, and ex-KGB Colonel Gradsky. They take on the job of finding 1000 grams of weapons-grade plutonium stolen from the Russian government, though they do not know the identity of their client.