石桥茶子（铃木美咲 配音）是一个普通的中学生，和其他的同龄人一样，个性朴实的她过着每日两点一线的生活。学校的生活虽然一成不变，但有着好友们的陪伴，日子却并不难熬，但有一件事情令茶子十分的在意，那就是这个坐在自己身旁的同桌柴犬子（佐佐木未来 配音）。
虽然身着水手服，说着和自己一样的语言，但无论从外表还是行为上来看，柴犬子都是一只不折不扣的雌性柴犬。可是，除了自己，周围的同学们似乎都没有发现她的异常。如果就此提出疑问，或许会被当成怪人也说不成，更糟糕的是，自己的行为可能会伤害到积极融入班级中的柴犬子。说还是不说？茶子陷入了深深的矛盾之中。

Fifteen year old Kuroki Tomoko has dated dozens of boys and is easily the most popular girl around — inside her dating games. In reality, she gets tongue tied just talking to people, and throughout middle school she's only had one actual friend. As she enters high school, she desperately wants to be popular, but doesn't understand that real-life doesn't work like her games. Her artificial successes pave the way to real folly and failure. But why drop this strategy when there's always someone else to blame?!

Mochizuki General Hospital boasts some of the most well-trained nurses in town. But though these ladies spend much of their day battling sickness, their after-hours are spent fighting a very different sort of disease... Under the leadership of the hospital chairman, a handful of staff members and local teenagers form a group of mercenary assassins, targeting the "cancers" of society and excising those individuals before their wickedness spreads.

A parody of the console wars, the series tells the story of two nations, the Segua Kingdom and Ninteldo Empire, locked in a struggle for dominance over the land of Consume.

Set in a futuristic world, there exist "Toys" which grant people superhuman abilities. This is responsible for a wave of crimes and necessitates employing Toy-using detectives to help solve them. Opera Kobayashi runs a detective agency, Milky Holmes, staffed by four aspiring young girl detectives who attend the Holmes Detective Academy, and each girl possesses their own unique Toy.