Duke Fergus falls for Ann 'Flaxen' Tarry in the Barbary Coast in turn-of-the-century San Francisco. He loses money to crooked gambler Boss Tito Morell, goes home, learns to gamble, and returns. After he makes a fortune, he opens his own place with Flaxen as the entertainer; but the 1906 quake destroys his place.

In 1890 Minnesota Christine Powell is the scheming head of the Powell dynasty, the richest mining empire of the era. But the Powell mine deposits are diminishing. The Mesabi range represents a whole new productive area but the rights to mine there are held by a young geological engineer, Kyle Ramlo. The latter reaches an impasse when he needs money to continue his experimentation with open-pit mining and goes to Miss Powell for financing. She displays great interest in both his inventive mining method and in him personally but secretly plots to destroy him and take over his Masabi rights. The gullible Ramlo falls into clutches while the girl he really loves, Cathy Norlund, tries desperately to open his eyes to Christine's scheme.

Never Give a Sucker an Even Break is a 1941 film about a man who wants to sell a film story to Esoteric Studios. On the way he gets insulted by little boys, beaten up for ogling a woman, and abused by a waitress. W. C. Fields' last starring role in a feature-length film.