A condemned thief wants to donate a kidney to an ill businessman in exchange for a lighter sentence.

龙门镖局本是束河镇赫赫有名的镖局，在原来的当家佟镖头死后却负债累累。水果贩子蔡八斗为了挣钱，到龙门镖局去讨债，却中了圈套，和平安票号的少主陆三金一同被关了起来。两人与镖局里佟镖头的遗孀盛秋月（袁咏仪 饰）、镖师温良恭、大夫邱璎珞、江湖儿女吕青橙和白敬祺等人不打不相识。后 陆三金更是收购了龙门镖局，并且为众人安排了职位，决定携众人之力，重振龙门镖局的旗鼓。在陆三金的苦心经营下，龙门镖局重上正轨，接到了第一单生意。然而，却有众多神秘势力正在虎视眈眈，企图将龙门镖局连根铲除.....
《龙门镖局》是宁财神继《武林外传》之后七年磨一剑推出的又一与时俱进的喜剧，由王勇执导。

Movie is set during a period of time when Japanese invaded China. The story is told from Gao's perspective, a soldier seeking revenge from the Japanese in trying to assassinate the visiting Japanese chief in command. In the process of plotting such scheme, he had a chance encounter with a local Mafia, lead by its charismatic leader Fang. Fang had a bandit of followers, of which one is Fang's sister. Fang in the past have rescued many of these followers using his own blood and as a result all the members in the bandit formed a life long bond and friendship. When Gao realizes he could use the firearms and man power of Fang's bandit, he sets up a scheme to get captured by Fang on purpose. When Fang found out - he was extremely angry and upset and almost killed Gao, but Gao is saved by Fang's sister because she clearly developed feelings for Gao after seeing how he fared during the interrogation phases when he was in Fang's capture.