FBI Agent Will Graham, who retired after catching Hannibal Lecktor, returns to duty to engage in a risky cat-and-mouse game with Lecktor to capture a new killer.

A psychiatrist temporarily separated from her family begins to experience severe psychological distress while working at a mental hospital and returning to her childhood home. As her professional responsibilities and personal relationships intersect, she undergoes a breakdown that forces her to confront long-suppressed memories and fears.

Chris McCormick (Margaux Hemingway), a high fashion and cosmetics model is brutally raped by her younger sister’s music teacher, Gordon Stuart (Sarandon). After pleading not guilty to the crime and being found innocent by a jury, Stuart finds a new victim in Chris’s younger sister and his own student, Kathy (Mariel Hemingway). Now even more enraged by the recent turn of events, Chris takes matters into her own hands as she seeks revenge for the crimes committed against both herself and her sister.

In Victorian England, a master criminal makes elaborate plans to steal a shipment of gold from a moving train.

Zharko, leader of the Romanis in NYC, passes his position of leadership on to his unwilling grandson, Dave, leading to infighting between Dave and his father.

Phoebe and fellow American Julian Peters meet in Rome, find a lost dog, and agree to return it to Monte Carlo to split the five thousand dollar reward. Discovering the dog's owner dead, they panic and become fugitives. Other victims of misfortune also become suspects, as the plot twists and luck and judgment desert everyone.