Lorna Blake, (Ursula Jeans) is a widow with two daughters. She augments her slender income by using her children to extort money - visiting the houses of the rich to tell a pathetic story and beg for help. And Lorna makes a rich capture when Sir Halmar Bernard, (Cecil Parker), proposes to her. She tells him that she has only one daughter, Molly (Jill Freud, credited as Jill Raymond). When her other daughter, Jay (Jean Simmons), is arrested for forging a cheque, she refuses to help her.

Based on the play by Ted Willis, the film is set in the years just before World War II, when England hadn't completely dug itself out of the worldwide depression. Melvyn Hayes is featured as an aimless teenager, who tries to escape his squalid surroundings by entering a life of crime. He falls in with local hoodlum Herbert Lom, who holds the rest of the slum citizens in the grip of fear including Hayes' own family. No Trees in the Street chronicles Hayes' sordid progress from nickel-and-dime thefts to murder.