A gang of vicious outlaws lead by the crazed Black Burt Keller abduct Jessica Colby and decide to flee to Mexico. Shrewd bounty hunter Django and saintly roving gunslinger Sartana join forces to rescue the poor lass from the gang's vile clutches.

Macho Callaghan is a lieutenant in the Federal Guards and his job is to capture Butch Cassidy, Ironhead, and their band of outlaws. Getting in touch with Ironhead, Macho finds a way of being hired by the outlaws. But when the two leaders quarrel and decide to separate, Macho manages to convince Ironhead to attack Butch Cassidy.

Sam is wounded by the Mash Flanigan gang who enters a saloon and kills everybody in sight including his brother. Walbash chases Flanigan to Golden City for revenge, leading to the obligatory showdown. One of the clever scenes is when gunfighters Gordon Mitchell, Lincoln Tate and Peter Martell interview for jobs and are introduced with their acting names Mitchell, Tate and Martell.