Some of Sin City's most hard-boiled citizens cross paths with a few of its more reviled inhabitants.

Restless and ready for an adventure, four suburban bikers leave the safety of their subdivision and head out on the open road. But complications ensue when they cross paths with an intimidating band of New Mexico bikers known as the Del Fuegos.

Phil and Claire Foster fear that their mild-mannered relationship may be falling into a stale rut. During their weekly date night, their dinner reservation leads to their being mistaken for a couple of thieves—and now a number of unsavoury characters want Phil and Claire killed.

After having successfully eluded the authorities for years, Hannibal peacefully lives in Italy in disguise as an art scholar. Trouble strikes again when he's discovered leaving a deserving few dead in the process. He returns to America to make contact with now disgraced Agent Clarice Starling, who is suffering the wrath of a malicious FBI rival as well as the media.

As Jimmy Keene begins a 10-year prison sentence, he gets an incredible offer: If he can elicit a confession from suspected killer Larry Hall, Jimmy will be freed. Completing this mission becomes the challenge of a lifetime.

Complete strangers stranded at a remote desert motel during a raging storm soon find themselves the target of a deranged murderer. As their numbers thin out, the travelers begin to turn on each other, as each tries to figure out who the killer is.