Investigative journalist Eddie Brock attempts a comeback following a scandal, but accidentally becomes the host of Venom, a violent, super powerful alien symbiote. Soon, he must rely on his newfound powers to protect the world from a shadowy organization looking for a symbiote of their own.

Struggling to find his place in the world while juggling school and family, Brooklyn teenager Miles Morales is unexpectedly bitten by a radioactive spider and develops unfathomable powers just like the one and only Spider-Man. While wrestling with the implications of his new abilities, Miles discovers a super collider created by the madman Wilson "Kingpin" Fisk, causing others from across the Spider-Verse to be inadvertently transported to his dimension.