A detective investigates a series of murders that he begins to suspect are being committed by a woman involved in prostitution and narcotics trafficking.

While tracking a ruthless killer, RoboCop and Madigan uncover a conspiracy between insane genius Dr. Cray Mallardo and ruthless OCP executive Chip Chayken, to develop a computer system linked to a human brain. Neuro-brain is created, a system capable of running the public services of the entire city. There's just one glitch: a ghost named Diana inhabits the machine. As RoboCop gets too close to this kindred spirit, Chayken enlists the aid of a homicidal psychopath Pudface Morgan to kill him off.