In the mid-19th century, Senator William J. Tadlock leads a group of settlers overland in a quest to start a new settlement in the Western US. Tadlock is a highly principled and demanding taskmaster who is as hard on himself as he is on those who have joined his wagon train. He clashes with one of the new settlers, Lije Evans, who doesn't quite appreciate Tadlock's ways. Along the way, the families must face death and heartbreak and a sampling of frontier justice when one of them accidentally kills a young Indian boy.

An American scientist is sent to Red China to steal the formula for a newly developed agricultural enzyme. What he is not told by his bosses is that a micro-sized bomb has been planted in his brain so that should the mission ever look likely to fail, he can be eliminated at the push of a button!

Truck driver Mike Lambert is a down-and-out mining engineer searching for a job. When his rig breaks down in a small town, he happens upon a venomous seductress. When her boyfriend robs a bank, they intend to frame Lambert.

During World War II, Italian villagers hide their wine from the German army.

The marital difficulties of four couples living in a southern California housing development become intertwined. Among the unhappy couples are ne'er-do-well Jerry Flagg and his long-suffering wife Isabelle, flirtatious Leola Boone and her sadistic husband Troy, hard-working Herman Kreitzer and his understanding wife Betty, and newlyweds Jean and David Martin.

The neighbors of a frontier family turn on them when it is suspected that their beloved adopted daughter was stolen from the Kiowa tribe.

Claude is a ruthless and efficient contract killer. His next target, a woman, is the most difficult.