Five teenage friends set out for the beach on their Spring Break vacation. Good times are cut short when one of the group, Carrie, contracts a deadly sexual transmitted disease during a bathroom stop. When they stop for the night at an isolated motel, the real terror begins when the STD virus starts running rampant, turning those infected into the living dead.

Strange things are happening in Druid Hills, Kentucky, known mainly for its voluminous corn output. Victims of monsters in cornfields begin cropping up, and witnesses are saying there are large Great White sharks swimming in the corn stalks.