Kwok Ching is a soon-to-retire television weatherman who really has long aspired to be a news anchor. At home, he's single-handedly brought up three children, but they are fed up with him meddling in their lives. His eldest daughter Mei Mei is a successful lawyer, and married to househusband Yao Ming. Tomboyish second daughter Ching Ching manages a supermarket and is in love with sissy promoter Lok Yi Nga. The youngest son Fu Shing is an otaku enamored with beautiful starlet Vivian and he unwittingly becomes the romantic rival of billionaire Roberto. Meanwhile, struck by the shocking news of the world's impending doom, Kwok Ching is determined that he must reunite his family before it's too late...

In the time of the Qing Dynasty, the Emperor Yongzheng created a secret army known as the Guillotines. It was the job of the Guillotines to protect the Emperor by killing anyone who posed a threat to him or his rule. After 348 successful missions to eliminate their target, the 349th assignment proves to be their last.