After a seven-year absence, Charlotte Andergast travels to Sweden to reunite with her daughter Eva. The pair have a troubled relationship: Charlotte sacrificed the responsibilities of motherhood for a career as a classical pianist. Over an emotional night, the pair reopen the wounds of the past. Charlotte gets another shock when she finds out that her mentally impaired daughter, Helena, is out of the asylum and living with Eva.

When disillusioned Swedish knight Antonius Block returns home from the Crusades to find his country in the grips of the Black Death, he challenges Death to a chess match for his life. Tormented by the belief that God does not exist, Block sets off on a journey, meeting up with traveling players Jof and his wife, Mia, and becoming determined to evade Death long enough to commit one redemptive act while he still lives.

As children in the loving Ekdahl family, Fanny and Alexander enjoy a happy life with their parents, who run a theater company. After their father dies unexpectedly, however, the siblings end up in a joyless home when their mother, Emilie, marries a stern bishop. The bleak situation gradually grows worse as the bishop becomes more controlling, but dedicated relatives make a valiant attempt to aid Emilie, Fanny and Alexander.

A young nurse, Alma, is put in charge of Elisabeth Vogler: an actress who is seemingly healthy in all respects, but will not talk. As they spend time together, Alma speaks to Elisabeth constantly, never receiving any answer.

Crotchety retired doctor Isak Borg travels from Stockholm to Lund, Sweden, with his pregnant and unhappy daughter-in-law, Marianne, in order to receive an honorary degree from his alma mater. Along the way, they encounter a series of hitchhikers, each of whom causes the elderly doctor to muse upon the pleasures and failures of his own life. These include the vivacious young Sara, a dead ringer for the doctor's own first love.