Escape-artist-mentalist-martial-arts superhero vs. mad scientist and monsters.

After facing defeat at the hands of Cristaldi the magician, Dracula is back to seek revenge and rule the world. With the help of Wolfman and his legion of followers, victory seems eminent. Professor Cristaldi, a descendant of the magician, is warned about Dracula's plans and calls upon El Santo and Blue Demon in the hopes that they can put the infamous Count and the werewolf down for good.

Luba, a werewolf woman, revives to destroy humanity. César Harker, a man who fights against the wolves, asks masked wrestling hero Santo for help, for he is the symbol of silver, the only thing that can destroy the wolves.