It's a hot summer day in 1933 in South Philly, where 12-year old Gennaro lives with his widowed mom and his ailing grandpa, who sits outside holding tight to his last quarter, which he's promised to Gennaro and which Gennaro would like to have to buy a ticket to the plush new movie theater. But grandpa's not ready to pass on the quarter or pass on to his final reward: he has some unfinished business with a woman from his past, and he enlists Gennaro to act as his emissary.

Mutant snakes survived a terrorist attack on a government laboratory, and they now threaten the town of Santa Mira Springs, California. Seismic activity has brought snakes to the surface, where residents are being bitten. Victims can transmit the virus to healthy persons. The military puts the town under quarantine. Local physicians try to control the epidemic, while the military is primarily concerned with keeping the virus a secret.

In the wake of a freak accident, Lance suffers the worst tragedy and the greatest opportunity of his life. He is suddenly faced with the possibility of fame, fortune and popularity, if he can only live with the knowledge of how he got there.