An innocent American engineer is blackmailed by gangsters into a plot to assassinate his cousin, who is a judge in Sicily fighting the Mafia.

An Italian policeman investigates a series of murders involving people in prominent positions. Left behind at each murder scene is a drawing of a salamander. The policeman begins to suspect these murders are linked to a plot to seize control of the government.

Based on the memoirs of author Curzio Malaparte, diplomatic liaison between the Allied and Italian forces after the defeat of the Nazis in Italy, The Skin follows the collapse of Italian society under the US occupation and the desperate measures required for survival.