Childhood chums Rocky Sullivan and Jerry Connelly grow up on opposite sides of the fence: Rocky matures into a prominent gangster, while Jerry becomes a priest, tending to the needs of his old tenement neighborhood.

When news reporter Walter Garrett arrives at the hotel room of bombshell actress Angela Merrova to conduct an interview, he finds her dead from multiple stab wounds. He returns with the police to find the hotel empty and the body vanished. Garrett writes about the incident but is fired when Merrova, alive and well, goes to the paper to complain. Now his only chance to get his job back is to find the truth, which involves the grisly scheme of a madman.

War heroes Rip Murdock and Johnny Drake are sent to Washington, D.C, to receive top honors for their service. Johnny, seemingly terrified by the publicity that awaits him, jumps off the train and later turns up dead. Suspecting foul play, Rip begins digging into his pal's past. He encounters cover-ups, threats to his own life and deadly femme fatale Coral Chandler.

Merchant Marine sailors Joe Rossi (Humphrey Bogart) and Steve Jarvis (Raymond Massey) are charged with getting a supply vessel to Russian allies as part of a sea convoy. When the group of ships comes under attack from a German U-boat, Rossi and Jarvis navigate through dangerous waters to evade Nazi naval forces. Though their mission across the Atlantic is extremely treacherous, they are motivated by the opportunity to strike back at the Germans, who sank one of their earlier ships.

When a US Naval captain shows signs of mental instability that jeopardize his ship, the first officer relieves him of command and faces court martial for mutiny.

In Libya, an American tank commander, along with a handful of Allied soldiers, tries to defend an isolated well with a limited supply of water from a German Afrika Korps battalion during the Western Desert Campaign of World War II.