An accidental overdose of gamma radiation causes a mutation in scientist David Banner's DNA: now whenever he becomes angry, he metamorphoses into a seven-foot-tall, 330-pound, mindless muscular green creature.

In one of the saga's most emotional stories, David Banner travels to Hawaii to find Dr. Caroline Fields, a psychiatrist who has developed a hypnotherapy technique that could cure him. Discovering they share the burden of an incurable condition—Caroline suffers from a terminal illness—the two fall in love and marry, offering Banner a glimpse of happiness. However, tragedy looms when Jack McGee's relentless pursuit and a devastating hurricane threaten their brief moment of peace.

After a band of drunken thugs overruns a small Indian Nation town, killing Reverend Goodnight and raping the women folk, Eula Goodnight enlists the aid of US Marshal Cogburn to hunt them down and bring her father's killers to justice.