Paris, 1910. Emile, a shy movie projectionist, and Raoul, a colourful inventor, find themselves embarked on the hunt for a monster terrorizing citizens. They join forces with Lucille, the big-hearted star of the Bird of Paradise cabaret, an eccentric scientist and his irascible monkey to save the monster, who turns out to be an oversized but harmless flea, from the city's ruthlessly ambitious police chief.

Mallory is the head of an elite government-run strike force dedicated to combating the supernatural. Her team includes the drag queen Vena Cava, an explosives expert; a mute, pre-teen telepath capable of possessing others named Talking Tina; and an armed governmental agent named Durand.