It's 1832, 22-year-old Raphaël's gambling has driven him to the brink of suicide. As he is about to throw himself in the Seine, a shopkeeper offers him something: a mysterious "skin of sorrow", which will grant all his wishes, but in doing so will shrink his remaining time on earth.

During a medical exam, Helena, a student in anatomical drawing, meets Benoit, a young radiologist. Their mutual fascination for the human body incites them to start a passionate romance. Helena's capability to memorize every detail of Benoit's body and Benoit's irresistible curiosity to uncover the 'interior' secrets of Helena's body lead them to a dangerous journey with no limits...

Ismael and Julie, in the hope of sparking their stalled relationship, enter a playful yet emotionally laced threesome with Alice. When tragedy strikes, these young Parisians are forced to deal with the fragility of life and love. For Ismael, this means negotiating through the advances of Julie's sister and a young college student – one of which may offer him redemption.