When terrorists threaten nuclear catastrophe at Chernobyl, the world's only hope is to reactivate decommissioned Universal Soldier Luc Deveraux. Rearmed and reprogrammed, Deveraux must take on his nemesis from the original Universal Soldier and a next-generation "UniSol" that seems almost unstoppable.

After his wife and daughter are murdered in a home invasion, a widower named John now finds himself up against an army of Universal Soldiers in relentless pursuit, led by a mysterious leader who promises to set UniSols free from their conditioning.