When New Orleans Police Detective Danny Fisher stops a brilliant thief from getting away with a multimillion-dollar heist, the thief's girlfriend is accidentally killed. After escaping from prison, the criminal mastermind enacts his revenge, taunting Danny with 12 rounds of near-impossible puzzles and tasks that he must somehow complete to save the life of the woman he loves.

After a woman jumps in front of a truck to save her daughter's life, she wakes up in the hospital in a seemingly alternate reality where everyone and everything in her life are different, including her own name.

A seasoned team of bank robbers, including Gordon Jennings, John Rahway, A.J., and brothers Jake and Jesse Attica successfully complete their latest heist and lead a life of luxury while planning their next job. When Ghost, a former member of their team, is released from prison he convinces the group to strike an armored car carrying $20 million. As the "Takers" carefully plot out their strategy and draw nearer to exacting the grand heist, a reckless police officer inches closer to apprehending the criminals.