Three women living in three different decades: a housewife in the '60s, a socialite in the '80s and a lawyer in 2018, deal with infidelity in their marriages.

Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.

When Jessica moves back into her childhood home with her family, her youngest stepdaughter Alice develops an eerie attachment to a stuffed bear named Chauncey she finds in the basement. Alice starts playing games with Chauncey that begin playful and become increasingly sinister. As Alice’s behavior becomes more and more concerning, Jessica intervenes only to realize Chauncey is much more than the stuffed toy bear she believed him to be.

The young daughter of a journalist disappears into the desert without a trace—eight years later, the broken family is shocked when she is returned to them, as what should be a joyful reunion turns into a living nightmare.

Two teenage Mexican-American loners in 1987 El Paso explore a new, unusual friendship and the difficult road to self-discovery.