Harley Cokeliss's Chicago Blues filmed in 1972 was a remarkable film; remarkable in that it was not just a competent documentary but a film crafted with care by professionals with a love and understanding of music and a respect for its history and artists. The music and its artists of Chicago Blues reflect faithfully the structure of the city's Blues activity of the late '60s from unknown amateur to world famous stars, from house to small bar, from traditional down home to modern city style. Thus Johnny Lewis, a housepainter who played for his own amusement at home and was almost a discovery of the film team, to Muddy Waters, Chicago Blues' most famous figure.

Finally released from prison, Elwood Blues is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children's hospital. Hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops.