In the twilight of the Ming Dynasty, the Imperial court is plagued by corruption as tyrants rule the land. With the Manchurians preying on a weakened empire, war is imminent. To save the victims from suffering, sorceress Jade Raksha fights the soldiers that oppress people for their own gain. As payback, local officials pin the murder of Governor Zhuo Zhonglian on Jade, turning her and the members of her cult into wanted fugitives for a crime they didn't commit.

In the time of the Qing Dynasty, the Emperor Yongzheng created a secret army known as the Guillotines. It was the job of the Guillotines to protect the Emperor by killing anyone who posed a threat to him or his rule. After 348 successful missions to eliminate their target, the 349th assignment proves to be their last.