An African-American woman becomes an unwitting pioneer for medical breakthroughs when her cells are used to create the first immortal human cell line in the early 1950s.

Tensions rise when the trailblazing Mother of the Blues and her band gather at a Chicago recording studio in 1927. Adapted from August Wilson's play.

Activist Bayard Rustin faces racism and homophobia as he helps change the course of Civil Rights history by orchestrating the 1963 March on Washington.