Prisme explore les relations et les identités de Marco et Andrea, deux jumeaux qui semblent identiques mais qui abordent la vie de manière très différente. Les jumeaux entament un voyage de découverte et de transition de ce qu'ils devraient être à ce qu'ils veulent être, ce qui impliquera également leur groupe d'amis, tous unis dans la recherche de leur place dans le monde.

Season 5 is the first to move past the original SKAM storylines, centering around Elia Santini. He struggles with toxic masculinity and sexual intimacy, as well as being forced to repeat his senior year of high school without his friends. Throughout the season, he finds himself drawn to classmate Viola.

Season 3 focused on Eleonora Sava. She lives with her older brother, completely independent from their parents, and prides herself on being wise beyond her years. However, her confidence threatens to come crashing down when she has to face her romantic feelings for Edoardo, a popular boy at school.

To honor her best friend's last wish, a young woman with severe anxiety confronts her greatest fears to try and reclaim her life — and perhaps find love.

Forced to repeat the last year of high school, Elia finds himself facing a new relationship, and dealing with self-esteem problems related to intimacy.