Vampires have come out of the shadows and are living as normal citizens. Two policemen, one a vampire, are assigned to track down a serial killer who tears the throat of his victims and drains their blood.

The world is falling into chaos. As he roams a crumbling city, Duncan MacLeod, the Highlander, remembers happier times before the love of his life left... Hopeless and alone, MacLeod finds his way to a band of immortal companions, including his mysterious friend Methos, and a mortal, Watcher Joe Dawson. Together this small group sets out on a quest to find the origin of the first Immortal.

Duncan MacLeod cannot die -- he is a 400-year-old immortal, who has seen his share of humanity's history. Still, he risks his life in battle against other immortals and tries to save people from harm.

Immortals Connor and Duncan Macleod join forces against a man from Connor's distant past in the highlands of Scotland, Kell, an immensely powerful immortal who leads an army of equally powerful and deadly immortal swordsmen and assassins. No immortal alive has been able to defeat Kell yet, and neither Connor nor Duncan are skilled enough themselves to take him on and live. The two of them eventually come to one inevitable conclusion; one of them must die so that the combined power of both the Highlanders can bring down Kell for good. There can be only one... the question is, who will it be?