The Amityville legend lives on when a resident of a local boarding house dies under mysterious circumstances. Her two best friends, Brigitta and Bermuda, Bermuda's sister Sentinel, and the owner of the boarding house, Ms. Ernie, are absolutely devastated. This is not helped by the arrival of an eccentric and crude detective who never takes off his cowboy outfit, Hank Denton. Tensions run high as the girls begin to suspect their friend Margaret may still be alive; and as the detective's behavior becomes more out of control, the house itself may very well be turning on it's residents.

Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.