Blossom Russo is a highly intelligent and spunky teenager. The youngest of three, she lives with her divorced musician father, Nick, eldest brother and recovering substance abuser Anthony, and decidedly not-so-bright middle brother Joey. Along for the ride is Blossom's ditzy best friend, Six, who sometimes shows flashes of great perception.

When a girl's friend is killed by a college hazing, she is the only one who can find out the truth.