Thirty-three years ago, an alien force known as the "JAM" invaded Earth through a dimensional portal over Antarctica. Earth’s forces managed to drive the JAM away to a distant planet designated as "Fairy." While the majority of Earth’s population is unaware of the JAM’s presence, the war continues on Fairy, where Rei Fukai is an SAF (Special Air Force) pilot assigned to pilot "Yukikaze"—an advanced reconnaissance fighter plane equipped with a near-sentient A.I. that detects the presence of the JAM within its path.

After a motocross accident, Sho Zama was pulled from Japan into the mystical world of Byston Well, where he and others from Earth were reicruited by Lord Drake Luft to pilot his newest weapons, the Aura Battlers, a combination of Byston Well magic and Earthien technology. However, in the heat of battle, Sho is approached by Marvel, a woman from Earth, who convinces him of Luft's sinister intentions.

Akira is just another normal kid in modern-day Tokyo, until an old friend of his, Ryo, shows up and turns his world upside down. Akira learns that there is an upcoming war of demons on humanity and he has just been enlisted for a major tour of duty. But the only way to fight a demon is with their power, so Akira and Ryo risk a dangerous ceremony in an attempt to create humanity's only hope: the powerful Devilman.

In the future, one can achieve immortality by obtaining a mechanized body. Orphaned, young Tetsuro hitches a ride on the space train Galaxy Express 999 in the hope of obtaining a cyborg body to avenge his mother's death. Along the way, he meets Maetel, who is the spitting image of his dead mother.