Hugely successful but impossibly neurotic songwriter Georgie Soloway is sliding into a mid-life crisis. He believes that all of his past romantic relationships have been destroyed not by his own failings but by the interference of the mysterious Harry Kellerman. Family, friends, and his psychiatrist cannot give him the help he seeks. When his father is diagnosed with a terminal illness, Georgie begins spending more and more time flying his personal aircraft, distancing himself physically, emotionally, and mentally from the real world.

Film version of the Neil Simon play has three separate acts set in the same hotel suite in New York's Plaza Hotel with Walter Matthau in a triple role. In the first, Karen Nash tries to get her inattentive husband Sam's attention and help save their failing marriage. In the second, brash film producer Jesse Kiplinger tries to seduce his former one-time flame Muriel. In the third, Roy Hubley and his wife Norma try and persuade their daughter, a bride to-be with cold feet, out of the bathroom before her approaching wedding ceremony.

Respected liberal Senator Joe Tynan is asked to to lead the opposition to a Supreme Court appointment. It means losing an old friend and fudging principles to make the necessary deals, as well as further straining his already part-time family life. But it could be a big boost to his career, so he takes it on. Helping him prepare the case is pretty southern researcher Karen Traynor, and their developing relationship further complicates and compromises his life.

Twelve-year-old Nick lives with his Uncle Murray, a Mr.Micawber-like Dickensian character who keeps hoping something won't turn up. What turns up is a social worker, who falls in love with Murray and a bit in love with Nick. As the child welfare people try to force Murray to become a conventional man (as the price they demand for allowing him to keep Nick), the nephew, who until now has gloried in his Uncle's iconoclastic approach to life, tries to play mediator. But when he succeeds, he is alarmed by the uncle's willingness to cave in to society in order to save the relationship.