The story of the coolest, street-smart hustler ever to walk the streets of Mexico City, based on the international hit song. The police are after him, his rivals are after him, and all the while the most beautiful women of Mexico are in the cup of his hand.

The kidnapping and murder of an innocent child leads agents Julián Carrera "Valentín Trujillo" and Roberto Rojas to investigate an organization led by Antonio Farcas and the ruthless Albina who engage in organ trafficking and drugs.