罹患脸盲症的傲娇郡王兼总捕头江心白（罗云熙 饰）秘密来到河蛮暗查“癸草案”时，意外结识了行事乖张、野蛮生长、并且每个月都变身的江湖游医颜南星（宋轶 饰）。二人不打不相识，为了各自身上隐藏的秘密，他们一起经历了“三结三离”的奇妙姻缘，最终携手扫除癸草之祸。

Zhang Qing, a present-day college student in culture and history major wants to study in professor Ye's postgraduate class, so he decides to write a historical fiction to elaborate his perspective of analyzing ancient literature history with modern concept. In the fiction, Zhang himself acts as a young man Fan Xian with mysterious life who lives in a remote seaside town of Kingdom Qing in his childhood, under the help of a mysterious mentor and a blindfolded watchman. Fan goes to the capital when he grows up, where he experiences plenty of ordeal and temper. Fan persists in adhering the rule of justice and goodness and lives his own glorious life.