Fifteen years after the original Woodsboro murders, Sidney Prescott returns home to promote her new book about surviving trauma, only for a new Ghostface killer to emerge, targeting a new group of teens.

Liza Miller, a suddenly single stay-at-home mother, tries to get back into the working world, only to find it’s nearly impossible to start at the bottom at 40-year old. When a chance encounter convinces her she looks younger than she is, Liza tries to pass herself off as 26 and lands a job as an assistant at Empirical Press. Now she just has to make sure no one finds out the secret only she and her best friend Maggie share.

A heroic group of teens sheltered from the dangers of the post-apocalyptic world receive a message that inspires them to leave the safety of the only home they have ever known and embark on a cross-country journey to find the one man who can possibly save the world.