Manchester, 1976. Tony Wilson is an ambitious but frustrated local TV news reporter looking for a way to make his mark. After witnessing a life-changing concert by a band known as the Sex Pistols, he persuades his station to televise one of their performances, and soon Manchester's punk groups are clamoring for him to manage them. Riding the wave of a musical revolution, Wilson and his friends create the legendary Factory Records label and The Hacienda club.

A solitary nurse bonds with a badly burned patient who survived an accident on an oil rig.

Seymour Krelborn is a nerdy orphan working at Mushnik's; a flower shop in urban Skid Row. He harbors a crush on fellow co-worker, Audrey Fulquard, and is berated by Mr. Mushnik daily. One day, Seymour finds a very mysterious unidentified plant which he calls Audrey II. The plant seems to have a craving for blood and soon begins to sing for his supper.