In season two, Dr. Paul Weston has divorced his wife Kate and moved from Maryland to a brownstone in Brooklyn, NY. Paul begins to rebuild his practice with a group of intriguing new patients while continuing to wrestle with some of the demons he left behind. Meanwhile, he commutes back to Maryland every Friday to continue his own sessions with Dr. Gina Toll.

In season one, therapist Dr. Paul Weston deals with five sets of patients, including an attractive woman with a crush on him, a scarred U.S. Air Force pilot, a suicidal teenage gymnast, and a couple on the verge of breaking up.