A brilliant, wheelchair-bound scientist invents a form of exo-skeleton called the Mechanically Augmented Neuro Transmitter Interception System (M.A.N.T.I.S.) that turns him into a superhero and gives him the ability to fight the crime wave that is engulfing his city.

After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!