The young and self-confident Danny bluffs at the local police-station that he will escape from prison within an hour. What follows is a flashback showing his childhood with his uncle and aunt, who are 'vaudeville'-artists themselves.

Susan and Lorenzo have been married for over five years and they are starting to drift apart. So into her life comes an angel, which only Susan can see, to tell her that there will be trouble ahead if they do not work out their problems. Lorenzo is developing insecticide #383 at Finlay Vega Chemical Co. and plans to test it on a camping trip that he takes with Susan, but the trip becomes an obstacle course for him.

Over fifty of the greatest living comedians are called to a party at Bob Hope's house, where each of them is systematically killed (and their bodies thrown in Hope's pool!). Hope and the rapidly shrinking cast try to discover who is the mysterious killer known only as "Joys."