Stef Foster, a dedicated police officer, and her partner Lena Adams, a school vice principal, have built a close-knit, loving family with Stef's biological son from a previous marriage, Brandon, and their adopted twins, Mariana and Jesus. Their lives are disrupted in unexpected ways when Lena meets Callie, a hardened teen with an abusive past who has spent her life in and out of foster homes. Lena and Stef welcome Callie and her brother, Jude, into their home thinking it's just for a few weeks, until a more permanent placement can be found. But life has something else in store for the Fosters.

Une fois leurs études terminées, Callie et Mariana, deux des enfants adoptifs de la famille Adams Foster, s'installent à Los Angeles où elles vont vivre leurs premiers pas d'adultes, entre défis, déboires professionnels, histoires d'amour, et nouvelles amitiés forgées au sein de leur logement communautaire.