For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.

Blade forms an uneasy alliance with the vampire council in order to combat the Reapers, who are feeding on vampires.

Have you ever sat by the phone wondering why he said he would call, but didn't, or you can't figure out why she doesn't want to sleep with you anymore, or why your relationship just isn't going to the next level... they're just not that into you. Gigi just wants a man who says he'll call—and does—while Alex advises her to stop waiting by the phone. Beth wants a proposal after years of a committed relationship with her boyfriend, Neil, who sees nothing wrong with the status quo. Janine's not sure if she can trust her husband, Ben, who can't quite trust himself around Anna. Anna can't decide between the sexy married guy, or her straightforward, no-sparks standby, Conor, who can't get over the fact that he can't have her. And Mary, who's found an entire network of loving, supportive men, just needs to find one who's straight.