Annie (Ann Gillis), an orphan, (based on Harold Gray's comic strip but who is at no point in the film called 'Little Orphan Annie), is befriended by a fight manager, 'Pop' Corrigan (J. Farrell MacDonald). She brings him Johnny Adams (Robert Kent), a promising prizefighter. Annie gets the people of the neighborhood to finance his training. But on the night of Johnny's big fight, a gambling syndicate locks him in a gymnasium and it appears the neighborhood folks will lose their investment.

Lawyer Perry Mason is summoned to the Laxter mansion in the dead of night to write granddaughter Wilma out of invalid Peter Laxter's will, to keep her from marrying suspected fortune hunter Doug. Peter dies in a mysterious fire and Laxter's two grandsons, Sam Laxter and Frank Oafley, inherit his estate on the condition old caretaker Schuster and his cat Clinker are kept on. When cat-hating Sam threatens Clinker, Perry steps in and learns Laxter's death was suspicious and the family fortune and diamonds are missing. Schuster's found dead in his basement apartment, Laxter's nurse Louise is murdered with Schuster's crutch, and circumstantial evidence brings Doug to trial for Louise's death. Mason's investigation produces a surprise witness who turns the trial around. Written by Sister Grimm